SCHEMBL2559627

SCHEMBL2559627

COc1ccc(F)cc1C1=CCC(Cl)(c2ccc3c(c2)CNCc2nncn2-3)CC1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 10/20 0.38
CDK9 P50750 10/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2556061 1.00 CCNT1 (0.38) CCNT1CDK9
Hydrochloric Acid SCHEMBL2558245 0.87 CYP11B2 (0.32)
SCHEMBL2560463 0.82
Hydrochloric Acid SCHEMBL2551927 0.82 OPRK1 (0.31)
Hydrochloric Acid SCHEMBL2559362 0.81 OPRK1 (0.37)
SCHEMBL2559625 0.81 CYP11B2 (0.32)
Hydrochloric Acid SCHEMBL2561790 0.81 CYP11B2 (0.32)
SCHEMBL2574375 0.81 CDK9 (0.35) CCNT1CDK9
Hydrochloric Acid SCHEMBL2548368 0.81 SLC6A3 (0.34)
SCHEMBL2563159 0.80 OPRK1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2558467-A1 ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E]AZULENES AS VASOPRESSIN ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2013-02-20 EP claimed
WO-2011128265-A1 ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E] AZULENES AS VASOPRESSIN ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2011-10-20 WO claimed
EP-2558467-A1 ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E]AZULENES AS VASOPRESSIN ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2013-02-20 EP disclosed
WO-2011128265-A1 ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E] AZULENES AS VASOPRESSIN ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2011-10-20 WO disclosed