Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11802315 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KDM4ECDK2RXFP1HPGD | |
| SCHEMBL7592034 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ACDK2QPCT | |
| SCHEMBL30729987 | 0.78 | ALDH1A1 (0.47) | ALDH1A1KDM4ERAB9ACDK2QPCT | |
| SCHEMBL11414191 | 0.74 | PDPK1 (0.51) | ALDH1A1TP53RAB9ACDK2HPGD | |
| SCHEMBL27535767 | 0.74 | XDH (0.47) | ALDH1A1KDM4EL3MBTL1RAB9ACDK2 | |
| SCHEMBL1371022 | 0.73 | ALDH1A1 (0.53) | ALDH1A1KDM4ETP53CDK2RXFP1 | |
| SCHEMBL28715732 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL29120496 | 0.73 | KDM4E (0.58) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL30578627 | 0.73 | POLB (0.49) | ALDH1A1KDM4ETP53RAB9ACDK2 | |
| SCHEMBL1079075 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KDM4ECDK2RXFP1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601622-B | 1- oxo/acylation -14- acylation Oridonin derivative, and its preparation method and application | 本生药业(上海)有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-107207525-B | The triptolide amino acid derivativges of C14- hydroxy esterifications, and its preparation method and application | 杭州卫本药业有限公司 | 2018-11-27 | — | — | CN | disclosed |
| CN-107898790-A | For treating or preventing the antiviral JAK inhibitor of retrovirus and other virus infection | 埃默里大学 | 2018-04-13 | — | — | CN | disclosed |
| CN-105418627-B | 1-oxo/acylation-14-acylated oridonin derivative, and preparation method and application thereof | 杭州本生药业有限公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-107709344-A | For treating the nucleoside analog of flaviviridae and cancer | 共晶制药股份有限公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-104039794-B | The hanfangchin B derivative of 7 substitutions, and its preparation method and application | 杭州本生药业有限公司 | 2017-11-03 | — | — | CN | disclosed |
| CN-107207404-A | Compound, its separation method, synthetic method and purposes | 北京北大维信生物科技有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107207525-A | The triptolide amino acid derivativges of C14 hydroxy esterifications, and its preparation method and application | 杭州卫本药业有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107108683-A | 2 ', 2' -dihalonucleoside analogs for the treatment of flaviviridae viruses and cancer | 共晶制药股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-104185420-B | Antiviral JAK inhibitors for the treatment or prevention of retroviral and other viral infections | 埃默里大学 | 2017-06-09 | — | — | CN | disclosed |
| CN-103945852-A | 2-substituted oleanolic acid derivative, method preparing for same, and application thereof | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD | 2014-07-23 | — | — | CN | disclosed |
| EP-2552916-B1 | PURINE COMPOUNDS USED AS CB2 AGONISTS | LILLY CO ELI (US) | 2014-05-21 | — | — | EP | disclosed |
| US-8710063-B2 | Purine compounds used as CB2 agonists | ELI LILLY AND COMPANY (US) | 2014-04-29 | — | — | US | disclosed |
| CN-103687859-A | Aminated derivative of homoharringtonine, preparation method therefor, and application thereof | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD | 2014-03-26 | — | — | CN | disclosed |
| CN-103635475-A | Tetrandrine derivative substituted by 5-carbon, and preparation method and application thereof | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD | 2014-03-12 | — | — | CN | disclosed |
| CN-103635476-A | Acylated derivative of homoharringtonine, preparation method therefor, and application thereof | HANGZHOU BENSHENG PHARMACEUTICAL CO LTD | 2014-03-12 | — | — | CN | disclosed |
| EP-2552916-A1 | PURINE COMPOUNDS USED AS CB2 AGONISTS | Eli Lilly and Company (US) | 2013-02-06 | — | — | EP | disclosed |
| US-20120329809-A1 | PURINE COMPOUNDS USED AS CB2 AGONISTS | ELI LILLY AND COMPANY (US) | 2012-12-27 | — | — | US | disclosed |
| CN-102803263-A | Purine compounds useful as CB2 agonists | LILLY CO ELI | 2012-11-28 | — | — | CN | disclosed |
| WO-2011123482-A1 | PURINE COMPOUNDS USED AS CB2 AGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329809-A1 | PURINE COMPOUNDS USED AS CB2 AGONISTS | CNR2, CNR1, P2RX7 | ALDH1A1 1891/4885KDM4E 4299/4885TP53 4794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.