Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMO | O15229 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455040 | 0.93 | ALDH1A1 (0.61) | POLBKMOALDH1A1TP53PRKAG1 | |
| SCHEMBL28094815 | 0.86 | PARP10 (0.56) | POLBKMOALDH1A1AKR1C3STK39 | |
| SCHEMBL17870007 | 0.86 | POLB (0.57) | POLBKMOALDH1A1AKR1C3SERPINE1 | |
| SCHEMBL12484035 | 0.83 | TYK2 (0.48) | POLBKMOALDH1A1TP53PRKAG1 | |
| SCHEMBL29039883 | 0.83 | KMO (0.48) | POLBKMOALDH1A1AKR1C3SERPINE1 | |
| SCHEMBL30287662 | 0.83 | POLB (0.77) | POLBALDH1A1AKR1C3SRD5A2KDM4E | |
| SCHEMBL522949 | 0.83 | POLB (0.77) | POLBALDH1A1AKR1C3SRD5A2KDM4E | |
| SCHEMBL12483371 | 0.83 | TDP1 (0.56) | KMOALDH1A1 | |
| SCHEMBL28576596 | 0.81 | POLB (0.75) | POLBALDH1A1AKR1C3SRD5A2KDM4E | |
| SCHEMBL2533361 | 0.80 | POLB (0.58) | POLBALDH1A1AKR1C3SRD5A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399416-B1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-11-02 | — | — | EP | claimed |
| EP-1399416-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-12-28 | — | — | EP | claimed |
| US-6852882-B2 | Peptide deformylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-08 | — | — | US | claimed |
| US-20040157916-A1 | Peptide deformylase inhibitors | GLAXOSMITHKLINE LLC | 2004-08-12 | — | — | US | claimed |
| EP-1399416-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-24 | — | — | EP | claimed |
| WO-2002098901-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1399416-B1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-1399416-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| US-6852882-B2 | Peptide deformylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-08 | — | — | US | disclosed |
| US-20040157916-A1 | Peptide deformylase inhibitors | GLAXOSMITHKLINE LLC | 2004-08-12 | — | — | US | disclosed |
| EP-1399416-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002098901-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157916-A1 | Peptide deformylase inhibitors | PDF, PEPD, DPEP1 | POLB 2001/4885KMO 4622/4885ALDH1A1 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.