SCHEMBL2564032

SCHEMBL2564032

NNC(=O)c1cccc(N)c1O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.64
ALDH1A1 P00352 5/20 0.50
GFER P55789 3/20 0.50
MAPT P10636 3/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
CTSD P07339 2/20 0.47
GAA P10253 2/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA9 Q16790 1/20 0.47
MITF O75030 1/20 0.47
NCOA1 Q15788 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
NCOA3 Q9Y6Q9 1/20 0.47
P2RX7 Q99572 1/20 0.46
KDM4E B2RXH2 2/20 0.46
NSD2 O96028 2/20 0.44
CFTR P13569 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7600310 0.87 MAPT (0.53) MMP2ALDH1A1GFERMAPTMEN1
SCHEMBL27859247 0.86 MMP2 (0.62) MMP2ALDH1A1GAAKDM4ENSD2
SCHEMBL12260753 0.84 MMP2 (0.60) MMP2ALDH1A1MAPTGAAKDM4E
SCHEMBL7986621 0.83 CTSD (0.47) MMP2ALDH1A1GFERMAPTMEN1
SCHEMBL112991 0.83 ALDH1A1 (0.55) ALDH1A1MAPTMEN1KMT2ACTSD
SCHEMBL189857 0.82 CTSD (0.46) MMP2ALDH1A1GFERMAPTMEN1
SCHEMBL29625279 0.82 CTSD (0.46) MMP2ALDH1A1GFERMAPTMEN1
SCHEMBL12310842 0.81 MMP2 (0.56) MMP2ALDH1A1MAPTMEN1KMT2A
SCHEMBL9243201 0.81 GAA (0.48) MMP2ALDH1A1GFERMAPTMEN1
SCHEMBL32018464 0.81 TERT (0.61) MMP2ALDH1A1GFERMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115666653-A Antibody-drug conjugates 斯皮雷亚有限公司 2023-01-31 CN disclosed
CN-113226378-A Antibody-drug conjugates 斯皮雷亚有限公司 2021-08-06 CN disclosed
EP-2560634-A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS Piramal Enterprises Limited (IN) 2013-02-27 EP disclosed
WO-2011132171-A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-10-27 WO disclosed