Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.50 |
| ▸ | GSK3B | P49841 | 7/20 | 0.50 |
| ▸ | PIM1 | P11309 | 6/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965915 | 0.96 | GSK3B (0.47) | ROCK2GSK3BPIM1AURKBRIPK2 | |
| SCHEMBL3380293 | 0.77 | TRPA1 (0.59) | ROCK2GSK3BPIM1AURKBAR | |
| SCHEMBL7572389 | 0.74 | TGFBR1 (0.50) | ROCK2GSK3BPIM1AURKBRIPK2 | |
| SCHEMBL30627398 | 0.74 | TGFBR1 (0.50) | ROCK2GSK3BPIM1AURKBRIPK2 | |
| SCHEMBL21632392 | 0.73 | AR (0.49) | ROCK2GSK3BPIM1AURKBRIPK2 | |
| SCHEMBL4960140 | 0.72 | PI4K2A (0.46) | RIPK2CHEK1BTKLCKKDM4E | |
| SCHEMBL17909871 | 0.72 | RIPK2 (0.51) | ROCK2GSK3BPIM1AURKBRIPK2 | |
| SCHEMBL29949712 | 0.71 | AR (0.63) | ROCK2ARCLK4DYRK1ACLK2 | |
| SCHEMBL1419814 | 0.71 | AR (0.63) | ROCK2ARCLK4DYRK1ACLK2 | |
| SCHEMBL5799577 | 0.71 | AR (0.63) | ROCK2ARCLK4DYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |