Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15008542 | 0.91 | MKNK1 (0.43) | NNMTKDM4E | |
| SCHEMBL2564973 | 0.88 | NNMT (0.40) | NNMTKDM4EVNN1 | |
| SCHEMBL15009129 | 0.84 | CCR6 (0.47) | — | |
| SCHEMBL27898833 | 0.81 | FPR2 (0.41) | VNN1 | |
| SCHEMBL2558289 | 0.80 | SCN9A (0.41) | ALDH1A1 | |
| SCHEMBL12294509 | 0.80 | ACSS2 (0.45) | — | |
| SCHEMBL6700940 | 0.80 | NNMT (0.59) | NNMTEPHX2HCAR3 | |
| SCHEMBL12288597 | 0.80 | VNN1 (0.44) | VNN1 | |
| SCHEMBL14990730 | 0.79 | FPR2 (0.43) | NNMTVNN1 | |
| SCHEMBL2563332 | 0.78 | LOXL2 (0.40) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160200717-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2016-07-14 | — | — | US | claimed |
| US-9994528-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994528-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994528-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-20160200717-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200717-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200717-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2016-07-14 | — | — | US | disclosed |
| EP-2560488-B1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2560488-B1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS INC (US) | 2015-10-28 | — | — | EP | disclosed |
| US-9133123-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133123-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133123-B2 | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use | CYTOKINETICS, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20130150368-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150368-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150368-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| EP-2560488-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | Cytokinetics, Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133920-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011133920-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | CYTOKINETICS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200717-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | SLC7A1, PRMT5, H1-5 | NNMT 1168/4885KDM4E 645/4885ALDH1A1 2669/4885 |
| US-20130150368-A1 | CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | SLC7A1, PRMT5, H1-5 | NNMT 1168/4885KDM4E 645/4885ALDH1A1 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.