Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 7/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 5/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16093786 | 0.84 | HASPIN (0.66) | HASPINDYRK2TP53CYP1A2CYP3A4 | |
| SCHEMBL16099365 | 0.83 | CYP2D6 (0.35) | HASPINCYP2D6MAOAMAOBADORA3 | |
| SCHEMBL16099174 | 0.83 | HASPIN (0.55) | HASPINDYRK2TP53CYP1A2CYP3A4 | |
| SCHEMBL16097995 | 0.82 | CYP2D6 (0.38) | HASPINCYP2D6ADORA3ADORA2ATDP1 | |
| SCHEMBL16099686 | 0.80 | NFATC1 (0.41) | CYP1A2CYP3A4CYP2D6ALOX15HIF1A | |
| SCHEMBL16100179 | 0.72 | PLK1 (0.43) | — | |
| SCHEMBL16093779 | 0.70 | HASPIN (0.71) | HASPINDYRK2TP53CYP1A2CYP3A4 | |
| SCHEMBL16097799 | 0.70 | ADORA3 (0.33) | ADORA3ADORA2A | |
| SCHEMBL16093913 | 0.69 | HASPIN (0.55) | HASPINDYRK2TP53CYP1A2CYP3A4 | |
| SCHEMBL15236168 | 0.69 | HASPIN (0.71) | HASPINDYRK2TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133795-A2 | BETA-CARBOLINES AS INHIBITORS OF HASPIN AND DYRK KINASES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-10-27 | — | — | WO | claimed |
| EP-2968284-A2 | ALKYL-AMINE HARMINE DERIVATIVES FOR PROMOTING BONE GROWTH | Osteoqc Inc. (CA) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153203-A2 | ALKYL-AMINE HARMINE DERIVATIVES FOR PROMOTING BONE GROWTH | OSSIFI INC. (US) | 2014-09-25 | — | — | WO | disclosed |