Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256578 | 0.83 | CTSL (0.64) | PDPK1POLBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19147143 | 0.81 | KDM4E (0.51) | KDM4EMAPK1PDPK1POLBALDH1A1 | |
| SCHEMBL6786495 | 0.79 | KDM4E (0.50) | KDM4EMAPK1PDPK1POLBALDH1A1 | |
| SCHEMBL2749368 | 0.79 | KDM4E (0.50) | KDM4EMAPK1PDPK1POLBALDH1A1 | |
| SCHEMBL6783400 | 0.79 | KDM4E (0.50) | KDM4EMAPK1PDPK1POLBALDH1A1 | |
| SCHEMBL7282665 | 0.76 | MTNR1A (0.53) | KDM4EMAPK1POLBALDH1A1HPGD | |
| SCHEMBL4765036 | 0.76 | KDM4E (0.47) | KDM4EMAPK1PDPK1POLBALDH1A1 | |
| SCHEMBL9424983 | 0.76 | KDM4E (0.64) | KDM4EMAPK1POLBALDH1A1HPGD | |
| SCHEMBL6434901 | 0.74 | KDM4E (0.48) | KDM4EMAPK1PDPK1POLBALDH1A1 | |
| SCHEMBL2736689 | 0.74 | PDPK1 (0.41) | KDM4EPDPK1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |