Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25664645 | 0.91 | ALDH1A1 (0.35) | ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL25880993 | 0.90 | ALDH1A1 (0.34) | ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL25664883 | 0.88 | ALDH1A1 (0.33) | ALDH1A1HTTLMNAKMT2AL3MBTL1 | |
| SCHEMBL25877474 | 0.88 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25664887 | 0.87 | ALDH1A1 (0.33) | ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL25664655 | 0.84 | CYP19A1 (0.30) | — | |
| SCHEMBL25664618 | 0.83 | MMP13 (0.43) | ALDH1A1HTTLMNAHTR6F10 | |
| SCHEMBL25881023 | 0.82 | — | — | |
| SCHEMBL25664722 | 0.82 | — | — | |
| SCHEMBL26270003 | 0.82 | ALDH1A1 (0.36) | ALDH1A1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760722-B2 | Inhibitors of cysteine proteases and methods of use thereof | ASCLETIS BIOSCIENCE CO., LTD. (CN) | 2023-09-19 | — | — | US | disclosed |
| US-20230159451-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | ASCLETIS BIOSCIENCE CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159451-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | SERPINB1, CTSV, CTSE | PSEN1 1491/4885PSEN2 1985/4885APH1B 1358/4885 |
| US-11760722-B2 | Inhibitors of cysteine proteases and methods of use thereof | SERPINB1, PREP, DNPEP | PSEN1 1310/4885PSEN2 1932/4885APH1B 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.