Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.49 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20818431 | 0.87 | TRPC5 (0.47) | P2RX3HDAC1HDAC6PDK2 | |
| SCHEMBL30476345 | 0.87 | TRPC5 (0.47) | P2RX3HDAC1HDAC6PDK2 | |
| SCHEMBL29875887 | 0.86 | P2RX3 (0.53) | P2RX3HDAC1HDAC6PTGDR2 | |
| SCHEMBL25280265 | 0.85 | P2RX3 (0.45) | P2RX3GRM5GRM1HDAC1HDAC6 | |
| SCHEMBL20831355 | 0.84 | P2RX3 (0.46) | P2RX3GRM5GRM1MAPT | |
| SCHEMBL25689217 | 0.84 | P2RX3 (0.44) | P2RX3C5AR1GRM5GRM1MAPT | |
| SCHEMBL20831354 | 0.84 | P2RX3 (0.44) | P2RX3GRM5GRM1MAPT | |
| SCHEMBL20831353 | 0.83 | P2RX3 (0.43) | P2RX3GRM5GRM1MAPT | |
| SCHEMBL20831356 | 0.83 | P2RX3 (0.45) | P2RX3GRM5GRM1MAPT | |
| SCHEMBL25688489 | 0.82 | HDAC1 (0.42) | P2RX3C5AR1GRM5GRM1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | PDXK, ATP6V1B1, REN | P2RX3 370/4885C5AR1 2303/4885GRM5 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.