Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30394182 | 0.86 | MERTK (0.35) | MPOMERTKADORA2AADORA2BADORA1 | |
| SCHEMBL25176721 | 0.86 | MERTK (0.35) | MPOMERTKADORA2AADORA2BADORA1 | |
| SCHEMBL25690422 | 0.85 | MPO (0.35) | MPOMEN1CYP1A2MAPTKMT2A | |
| SCHEMBL31465510 | 0.80 | ADORA2A (0.36) | MEN1CYP1A2KMT2AMERTKADORA2A | |
| SCHEMBL25176561 | 0.79 | DUT (0.36) | TNK2 | |
| SCHEMBL30968152 | 0.77 | PDE2A (0.39) | CYP1A2KMT2A | |
| SCHEMBL25690433 | 0.76 | LRRK2 (0.35) | MEN1MAPTKMT2AATMLRRK2 | |
| SCHEMBL30095837 | 0.72 | PDE2A (0.39) | — | |
| SCHEMBL2804826 | 0.72 | PDE2A (0.39) | — | |
| SCHEMBL25167836 | 0.71 | MERTK (0.37) | MERTKLRRK2TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780851-B2 | LRRK2 inhibitors | H. LUNDBECK A/S (DK) | 2023-10-10 | — | — | US | disclosed |
| US-20230144725-A1 | LRRK2 INHIBITORS | H. LUNDBECK A/S (DK) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780851-B2 | LRRK2 inhibitors | LRRK2, PARK7, PINK1 | MPO 3747/4885MEN1 3752/4885CYP1A2 4261/4885 |
| US-20230144725-A1 | LRRK2 INHIBITORS | LRRK2, PARK7, PINK1 | MPO 3747/4885MEN1 3752/4885CYP1A2 4261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.