Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446958 | 0.87 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL19023824 | 0.82 | GABRA1 (0.34) | KMT2AMEN1 | |
| SCHEMBL24233010 | 0.79 | CES2 (0.41) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL29112171 | 0.77 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL30329080 | 0.77 | ADORA2A (0.38) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL1258669 | 0.76 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL601042 | 0.74 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL29955062 | 0.74 | MGLL (0.38) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL603692 | 0.73 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 | |
| SCHEMBL31347570 | 0.73 | NT5E (0.37) | HSP90AA1HSP90AB1LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372836-B2 | Spray dried formulation | BEND RESEARCH, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| EP-1987030-B1 | 3 -DEAZAPURINE DERIVATIVES AS TLR7 MODULATORS | PFIZER LTD (GB) | 2011-11-09 | — | — | EP | disclosed |
| EP-2101741-B1 | SOLID DISPERSION COMPRISING A POORLY WATER SOLUBLE DRUG | BEND RES INC (US) | 2010-08-11 | — | — | EP | disclosed |
| US-7691877-B2 | Pharmaceuticals | PFIZER INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20100029667-A1 | Spray dried formulation | BEND RESEARCH INC. | 2010-02-04 | — | — | US | disclosed |
| EP-2101741-A2 | SOLID DISPERSION COMPRISING A POORLY WATER SOLUBLE DRUG | BEND RESEARCH, INC. (US) | 2009-09-23 | — | — | EP | disclosed |
| EP-1987030-A1 | 3 -DEAZAPURINE DERIVATIVES AS TLR7 MODULATORS | Pfizer Limited (GB) | 2008-11-05 | — | — | EP | disclosed |
| WO-2008047201-A2 | SOLID DISPERSION COMPRISING A POORLY WATER SOLUBLE DRUG | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |
| WO-2007093901-A1 | 3 -DEAZAPURINE DERIVATIVES AS TLR7 MODULATORS | PFIZER LIMITED (GB) | 2007-08-23 | — | — | WO | disclosed |
| US-20070197478-A1 | NOVEL PHARMACEUTICALS | PFIZER LIMITED | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197478-A1 | NOVEL PHARMACEUTICALS | TLR3, HAVCR2, TLR9 | HSP90AA1 1297/4885HSP90AB1 868/4885LMNA 4120/4885 |
| US-20100029667-A1 | Spray dried formulation | PRKG1, PDE7A, PDE10A | HSP90AA1 2556/4885HSP90AB1 3269/4885LMNA 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.