Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541442 | 0.85 | — | — | |
| SCHEMBL1995648 | 0.81 | CES1 (0.41) | ALDH1A1LMNAHSD17B10CA12CA1 | |
| SCHEMBL1066094 | 0.79 | DGKA (0.44) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL9629142 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL9628764 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL9630878 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL9629133 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL2199092 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL9629173 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 | |
| SCHEMBL9629686 | 0.77 | DGKA (0.48) | ALDH1A1HSD17B10ALOX15CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102641-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2013-04-25 | — | — | US | claimed |
| US-7790708-B2 | Prodrugs of GABA analogs, compositions and uses thereof | XENOPORT, INC. (US) | 2010-09-07 | — | — | US | claimed |
| CN-101381339-A | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2009-03-11 | — | — | CN | claimed |
| JP-4216713-B2 | — | — | 2009-01-28 | — | — | JP | claimed |
| EP-1902714-A1 | Prodrugs of gaba analogs, compositions and uses thereof | Xenoport, Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| EP-1404324-B1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT INC (US) | 2007-12-05 | — | — | EP | claimed |
| US-7060727-B2 | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof | XENOPORT, INC. (US) | 2006-06-13 | — | — | US | claimed |
| CN-1753673-A | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2006-03-29 | — | — | CN | claimed |
| EP-1404324-A4 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT INC (US) | 2004-12-22 | — | — | EP | claimed |
| JP-2004536873-A | — | — | 2004-12-09 | — | — | JP | claimed |
| US-20040147455-A1 | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof | XENOPORT, INC. | 2004-07-29 | — | — | US | claimed |
| WO-2004052360-A1 | PRODRUGS OF FUSED GABA ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2004-06-24 | — | — | WO | claimed |
| EP-1404324-A2 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | Xenoport, Inc. (US) | 2004-04-07 | — | — | EP | claimed |
| US-20030176398-A1 | Prodrugs of GABA analogs, compositions and uses thereof | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2003-09-18 | — | — | US | claimed |
| WO-2002100347-A2 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2002-12-19 | — | — | WO | claimed |
| US-5217985-A | RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | claimed |
| US-5120849-A | Reacting cyclic imidoether with aminoalcohol | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-09 | — | — | US | claimed |
| US-20160090353-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2016-03-31 | — | — | US | disclosed |
| EP-0244786-B1 | PROCESS FOR PREPARING 0-SUBSTITUTED HYDROXYLAMINES | BASF Aktiengesellschaft (DE) | 1991-03-06 | — | — | EP | disclosed |
| EP-0244786-A1 | Process for preparing 0-substituted hydroxylamines | BASF Aktiengesellschaft (DE) | 1987-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160090353-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885LMNA 3012/4885HSD17B10 734/4885 |
| US-20130102641-A1 | PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885LMNA 3012/4885HSD17B10 734/4885 |
| US-20030176398-A1 | Prodrugs of GABA analogs, compositions and uses thereof | GABRB1, GABRB2, GABRB3 | ALDH1A1 298/4885LMNA 3012/4885HSD17B10 734/4885 |
| US-20040147455-A1 | Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof | GABRB1, GABRB2, GABRB3 | ALDH1A1 380/4885LMNA 3012/4885HSD17B10 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.