SCHEMBL257434

SCHEMBL257434

Nc1nc(-c2cccc(Cl)c2)c(C(=O)c2ccccc2F)s1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORB Q92753 19/20 0.79
RORC P51449 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL257572 0.88 RORB (1.00) RORBRORC
SCHEMBL256653 0.87 RORB (0.59) RORBRORC
SCHEMBL257269 0.86 RORB (0.60) RORBRORC
SCHEMBL257432 0.83 RORB (0.74) RORBRORC
SCHEMBL257436 0.82 RORB (0.66) RORBRORC
SCHEMBL257615 0.82 RORB (0.72) RORBRORC
SCHEMBL10092890 0.81 RORB (0.65) RORBRORC
SCHEMBL10092885 0.81 RORB (0.70) RORBRORC
SCHEMBL2493975 0.80 RORB (0.69) RORB
SCHEMBL10092883 0.78 RORB (0.67) RORBRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012027965-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 WO disclosed