Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 12/20 | 0.74 |
| ▸ | RORC | P51449 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257615 | 0.94 | RORB (0.72) | RORBRORCADORA2ACCNA2CDK2 | |
| SCHEMBL10092883 | 0.92 | RORB (0.67) | RORBRORCADORA3ADORA2AADORA1 | |
| SCHEMBL10092885 | 0.92 | RORB (0.70) | RORBRORCADORA3ADORA2AADORA1 | |
| SCHEMBL257436 | 0.89 | RORB (0.66) | RORBRORCLMNA | |
| SCHEMBL10092890 | 0.88 | RORB (0.65) | RORBRORCCCNA2CDK2 | |
| SCHEMBL165773 | 0.86 | ADORA3 (0.61) | RORBADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL178218 | 0.85 | ADORA3 (0.60) | RORBRORCADORA3ADORA2AADORA1 | |
| SCHEMBL257616 | 0.85 | ADORA3 (0.64) | RORBADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL257572 | 0.85 | RORB (1.00) | RORBRORC | |
| SCHEMBL257393 | 0.85 | RORB (0.60) | RORBRORCADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |