Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25745966 | 0.80 | EGLN2 (0.39) | ALDH1A1HDAC3HDAC1 | |
| SCHEMBL25745961 | 0.80 | LMNA (0.48) | NAMPTMAOBGCGRHDAC6LMNA | |
| SCHEMBL25745940 | 0.78 | FPR2 (0.58) | — | |
| SCHEMBL25745964 | 0.76 | MAOB (0.45) | NAMPTMAOBGCGRHDAC3HDAC1 | |
| SCHEMBL25745959 | 0.75 | NAMPT (0.68) | NAMPTALDH1A1HDAC3HDAC1HDAC8 | |
| SCHEMBL25745949 | 0.71 | KIT (0.53) | NAMPTMAOBHDAC6 | |
| SCHEMBL25745885 | 0.70 | NAMPT (0.48) | NAMPTMAOBALDH1A1HDAC3HDAC1 | |
| SCHEMBL21379406 | 0.67 | NAMPT (0.48) | NAMPTMAOBGCGRHDAC3HDAC1 | |
| SCHEMBL24003401 | 0.65 | MAOB (0.49) | NAMPTMAOB | |
| SCHEMBL13536072 | 0.63 | KDR (0.44) | NAMPTALDH1A1SMN1; SMN2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |