Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.35 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.35 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25625286 | 0.92 | POLB (0.42) | POLBMEN1KMT2AKCNA5THRB | |
| SCHEMBL24036757 | 0.87 | POLB (0.39) | POLBMEN1KMT2AITGB3ITGAV | |
| SCHEMBL24036756 | 0.86 | POLB (0.38) | POLBMEN1KMT2AITGB3ITGAV | |
| SCHEMBL25754075 | 0.85 | WDR5 (0.37) | POLBMEN1KMT2AITGB3ITGAV | |
| SCHEMBL24036842 | 0.83 | NOTUM (0.44) | POLBMEN1KMT2AITGB3ITGAV | |
| SCHEMBL25625381 | 0.82 | POLB (0.36) | POLBMEN1KMT2ATHRBTACR3 | |
| SCHEMBL24036727 | 0.82 | KCNA5 (0.47) | POLBMEN1KMT2AKCNA5TACR3 | |
| SCHEMBL25625085 | 0.81 | THRB (0.36) | POLBITGB3ITGAVITGB5ITGB6 | |
| SCHEMBL24036824 | 0.81 | ITGB3 (0.40) | POLBMEN1KMT2AITGB3ITGAV | |
| SCHEMBL25753874 | 0.79 | MAPT (0.39) | POLBMEN1KMT2AITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | DHFR, DPYD, CYP2D6 | POLB 860/4885MEN1 431/4885KMT2A 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.