SCHEMBL25754478

SCHEMBL25754478

CC#CC(O)C(N)CCN1CCCCC1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.37
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HRH3 Q9Y5N1 4/20 0.33
ALDH1A1 P00352 2/20 0.32
MAPT P10636 2/20 0.32
ANPEP P15144 1/20 0.32
ERAP2 Q6P179 1/20 0.32
TSHR P16473 1/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25754498 0.81 HRH3 (0.33) LMNAKMT2AHRH3ALDH1A1TSHR
SCHEMBL25754502 0.78 LMNA (0.35) LMNAMEN1KMT2AL3MBTL1HRH3
SCHEMBL25754525 0.73 HRH3 (0.32) LMNAHRH3ALDH1A1
Hydroxyamine SCHEMBL1454400 0.72 L3MBTL1 (0.50) LMNAMEN1KMT2AL3MBTL1HRH3
SCHEMBL10510078 0.69 HRH3 (0.49) LMNAMEN1KMT2AL3MBTL1HRH3
SCHEMBL1455583 0.69 HRH3 (0.49) LMNAMEN1KMT2AL3MBTL1HRH3
SCHEMBL25754390 0.69 LMNA (0.35) LMNAL3MBTL1HRH3MAPTANPEP
SCHEMBL25754249 0.69 HRH3 (0.38) MEN1KMT2AHRH3ALDH1A1MAPT
SCHEMBL25754591 0.69 HRH3 (0.38) MEN1KMT2AHRH3ALDH1A1MAPT
SCHEMBL8553534 0.68 HRH3 (0.44) LMNAL3MBTL1HRH3ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM UCHL3, UBE2L3, ADAM33 LMNA 1517/4885MEN1 940/4885KMT2A 1974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.