SCHEMBL25756505

SCHEMBL25756505

C#CCCCNCCCNC(=O)C(F)(F)F

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA3 P07451 2/20 0.70
CA5A P35218 2/20 0.70
CA5B Q9Y2D0 2/20 0.70
CA14 Q9ULX7 2/20 0.70
CA2 P00918 2/20 0.70
CA12 O43570 1/20 0.70
CA4 P22748 1/20 0.70
CA6 P23280 1/20 0.70
CA7 P43166 1/20 0.70
CA9 Q16790 1/20 0.70
SMN1; SMN2 Q16637 3/20 0.57
ALDH1A1 P00352 2/20 0.57
POLB P06746 1/20 0.57
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
EPHX1 P07099 1/20 0.47
GLA P06280 1/20 0.46
HPGD P15428 1/20 0.46
ALOX12 P18054 1/20 0.46
MAPT P10636 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6819313 0.93 ALDH1A1 (0.65) CA3CA5ACA5BCA14CA2
SCHEMBL6816081 0.87 ALDH1A1 (0.69) CA3CA5ACA5BCA14CA2
SCHEMBL9369234 0.86 MEN1 (0.70) CA3CA5ACA5BCA14CA2
SCHEMBL6815862 0.86 MEN1 (0.70) CA3CA5ACA5BCA14CA2
SCHEMBL3142216 0.85 CA3 (0.95) CA3CA5ACA5BCA14CA2
SCHEMBL1274081 0.83 CA3 (1.00) CA3CA5ACA5BCA14CA2
SCHEMBL10228415 0.83 CA3 (1.00) CA3CA5ACA5BCA14CA2
SCHEMBL12936102 0.83 CA3 (1.00) CA3CA5ACA5BCA14CA2
SCHEMBL25766761 0.83 CA3 (0.56) CA3CA5ACA5BCA14CA2
SCHEMBL13787269 0.81 ALDH1A1 (0.58) CA3CA5ACA5BCA14CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM UCHL3, UBE2L3, ADAM33 CA3 2556/4885CA5A 4399/4885CA5B 4366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.