SCHEMBL2575691

SCHEMBL2575691

CC(=O)NC1CCc2cc(C(C)=O)ccc21

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.63
CA1 P00915 2/20 0.63
CA2 P00918 2/20 0.63
CA7 P43166 2/20 0.63
CA9 Q16790 2/20 0.63
CA14 Q9ULX7 2/20 0.63
ALDH1A1 P00352 1/20 0.49
TOP2A P11388 1/20 0.46
TOP2B Q02880 1/20 0.46
KMT2A Q03164 3/20 0.45
PDE4A P27815 1/20 0.45
PDE4B Q07343 1/20 0.45
PDE4C Q08493 1/20 0.45
PDE4D Q08499 1/20 0.45
TUBB1 Q9H4B7 4/20 0.45
LMNA P02545 3/20 0.45
CYP2C9 P11712 3/20 0.45
TSHR P16473 2/20 0.45
RAB9A P51151 2/20 0.45
TUBB4A P04350 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2575983 0.90 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL2575564 0.87 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL24120 0.86 CA12 (0.48) CA12CA1CA2CA7CA9
SCHEMBL10588697 0.85 CA12 (0.56) CA12CA1CA2CA7CA9
SCHEMBL14890213 0.84 CA12 (0.55) CA12CA1CA2CA7CA9
SCHEMBL14890057 0.84 NPC1 (0.48) CA12CA1CA2CA7CA9
SCHEMBL10586238 0.83 CA1 (0.64) CA12CA1CA2CA7CA9
SCHEMBL14902975 0.83 CA12 (0.45) CA12CA1CA2CA7CA9
SCHEMBL14890086 0.83 CA12 (0.45) CA12CA1CA2CA7CA9
SCHEMBL2554893 0.83 PKM (0.47) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130109757-A1 PROCESS FOR THE PREPARATION OF PYRROLINES FROM GAMMA-NITROKETONES. USE OF THE GAMMA-NITROKETONES AS PESTICIDAL AGENTS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-05-02 US disclosed
EP-2558444-A1 PROCESS FOR THE PREPARATION OF PYRROLINES FROM GAMMA-NITROKETONES. USE OF THE GAMMA-NITROKETONES AS PESTICIDAL AGENTS Bayer Intellectual Property GmbH (DE) 2013-02-20 EP disclosed
WO-2011128299-A1 PROCESS FOR THE PREPARATION OF PYRROLINES FROM GAMMA-NITROKETONES. USE OF THE GAMMA-NITROKETONES AS PESTICIDAL AGENTS BAYER CROPSCIENCE AG (DE) 2011-10-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130109757-A1 PROCESS FOR THE PREPARATION OF PYRROLINES FROM GAMMA-NITROKETONES. USE OF THE GAMMA-NITROKETONES AS PESTICIDAL AGENTS NOS2, PDXK, GSTK1 CA12 3988/4885CA1 1150/4885CA2 603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.