Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 12/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25813024 | 1.00 | ATF4 (0.40) | ATF4HCRTR1ALDH1A1HPGDTSHR | |
| SCHEMBL25781454 | 0.94 | ALDH1A1 (0.37) | ATF4HCRTR1ALDH1A1GAATNKS | |
| SCHEMBL19568855 | 0.88 | ATF4 (0.43) | ATF4HCRTR1ALDH1A1HPGDTSHR | |
| SCHEMBL20992782 | 0.87 | ATF4 (0.45) | ATF4BACE1 | |
| SCHEMBL25812808 | 0.86 | ALDH1A1 (0.46) | ATF4ALDH1A1HPGDTSHRGAA | |
| SCHEMBL19556230 | 0.85 | ATF4 (0.50) | ATF4BACE1 | |
| SCHEMBL25804759 | 0.83 | RXFP1 (0.43) | ATF4ALDH1A1GAA | |
| SCHEMBL20992455 | 0.83 | ATF4 (0.50) | ATF4BACE1 | |
| SCHEMBL25813019 | 0.81 | ATF4 (0.45) | ATF4BACE1 | |
| SCHEMBL19568400 | 0.80 | SSTR3 (0.44) | ATF4ALDH1A1HPGDTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |