Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10967694 | 0.83 | COMT (0.49) | POLBHSD11B1GAAGFERCNR1 | |
| SCHEMBL25020313 | 0.80 | CCR2 (0.51) | POLBHSD11B1AKR1B1CNR1ALDH1A1 | |
| SCHEMBL25873556 | 0.80 | MEN1 (0.46) | HSD11B1GAAAKR1B1CNR1PKM | |
| SCHEMBL28793992 | 0.80 | CA2 (0.42) | POLBHSD11B1GAAGFERCNR1 | |
| SCHEMBL1990245 | 0.79 | LMNA (0.55) | HSD11B1AKR1B1PKMLMNATP53 | |
| SCHEMBL2350373 | 0.76 | AKR1B1 (0.51) | POLBHSD11B1GAAGFERAKR1B1 | |
| SCHEMBL7938049 | 0.76 | ALOX15 (0.62) | GAAHSD17B2PKMLMNAALOX15 | |
| SCHEMBL24311147 | 0.73 | FEN1 (0.44) | HSD11B1HSD17B2CNR1PKMLMNA | |
| SCHEMBL2909345 | 0.73 | PKM (0.53) | HSD11B1GAAAKR1B1CNR1PKM | |
| SCHEMBL13758572 | 0.72 | LMNA (0.44) | POLBGAAGFERLMNAKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752496-B1 | METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION | GILEAD SCIENCES INC (US) | 2023-07-05 | — | — | EP | disclosed |