Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690183 | 0.85 | PLA2G2A (0.62) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30007780 | 0.85 | ALDH1A1 (0.47) | ALDH1A1MAPTL3MBTL1LMNAADRA1D | |
| SCHEMBL27531161 | 0.82 | PLA2G2A (0.48) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7054203 | 0.82 | ADRA1D (0.49) | CCR2ADRA1D | |
| SCHEMBL27525760 | 0.81 | PLA2G2A (0.47) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30008203 | 0.81 | BRD4 (0.46) | ALDH1A1PLA2G2APLA2G1BCCR2ADRA1D | |
| SCHEMBL6773052 | 0.81 | PLA2G2A (0.50) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7056324 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6984365 | 0.81 | PLA2G2A (0.55) | ALDH1A1MAPTPLA2G2ALMNAMEN1 | |
| SCHEMBL6782169 | 0.80 | PLA2G2A (0.56) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137390-A1 | TREATMENT OF MAJOR ADVERSE CARDIAC EVENTS AND ACUTE CORONARY SYNDROME IN DIABETIC PATIENTS USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITOR OR SPLA2 INHIBITOR COMBINATION THERAPIES | ANTHERA PHARMACEUTICALS, INC. (US) | 2011-11-03 | — | — | WO | disclosed |