Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589797 | 0.88 | ROCK2 (0.55) | DRD4DRD2HDAC3HDAC4HDAC7 | |
| SCHEMBL2590019 | 0.73 | HIF1A (0.68) | HIF1AMAPT | |
| SCHEMBL13845583 | 0.71 | HIF1A (0.55) | TEAD1DRD4DRD2HTR2ASLC6A5 | |
| SCHEMBL2581672 | 0.71 | DRD4 (0.53) | TEAD1DRD4DRD2HTR2AHDAC3 | |
| SCHEMBL22719884 | 0.71 | TEAD1 (1.00) | TEAD1DRD4DRD2HTR2ASIGMAR1 | |
| SCHEMBL22731677 | 0.71 | TEAD1 (1.00) | TEAD1DRD4DRD2HTR2ASIGMAR1 | |
| SCHEMBL22719680 | 0.71 | TEAD1 (1.00) | TEAD1DRD4DRD2HTR2ASIGMAR1 | |
| SCHEMBL2585658 | 0.71 | CCR2 (0.46) | TEAD1DRD4DRD2HTR2AHDAC3 | |
| SCHEMBL8712569 | 0.70 | DRD4 (1.00) | DRD4DRD2HTR2AHDAC3HDAC4 | |
| SCHEMBL24529887 | 0.70 | DRD4 (0.66) | TEAD1DRD4DRD2HTR2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |