Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25813246 | 0.90 | LMNA (0.50) | ALDH1A1HTTSMN1; SMN2NAMPTKDM4E | |
| SCHEMBL25811758 | 0.80 | RAD52 (0.59) | TLR9TLR8TLR7NAMPTMAPT | |
| SCHEMBL25811770 | 0.80 | KMT2A (0.66) | TLR9TLR8TLR7ALDH1A1MAPT | |
| SCHEMBL25811293 | 0.77 | MAPT (0.65) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL30312302 | 0.77 | MAPT (0.65) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL25811207 | 0.75 | TLR8 (0.64) | TLR9TLR8TLR7ALDH1A1HTT | |
| SCHEMBL25813788 | 0.75 | MAPT (0.48) | ALDH1A1HTTSMN1; SMN2NAMPTMAPT | |
| SCHEMBL30046741 | 0.72 | ALDH1A1 (0.73) | ALDH1A1USP2HTTSMN1; SMN2NAMPT | |
| SCHEMBL14435527 | 0.71 | SMN1; SMN2 (0.61) | ALDH1A1USP2HTTSMN1; SMN2MAPT | |
| SCHEMBL2161339 | 0.71 | THRB (0.71) | ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | GALYAN BIO INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, HYPK, PARK7 | TLR9 4628/4885TLR8 4582/4885TLR7 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.