Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2571385 | 0.86 | PTGDR2 (0.41) | KCNH2GRIN2BMETJAK2FLT3 | |
| SCHEMBL2582687 | 0.85 | ROCK2 (0.35) | KCNH2GRIN2B | |
| SCHEMBL2580572 | 0.84 | TGFBR1 (0.32) | — | |
| SCHEMBL2573868 | 0.83 | PTGDR2 (0.33) | KCNH2GRIN2BMETJAK2FLT3 | |
| SCHEMBL2579240 | 0.83 | PTGDR2 (0.34) | — | |
| SCHEMBL533986 | 0.80 | AR (0.36) | — | |
| SCHEMBL2574953 | 0.78 | PTGDR2 (0.44) | — | |
| SCHEMBL2580081 | 0.77 | USP1 (0.32) | GRIN2B | |
| SCHEMBL2570608 | 0.76 | KCNH2 (0.36) | KCNH2 | |
| SCHEMBL2580577 | 0.75 | TGFBR1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139881-B1 | QUINOLINES AND THEIR THERAPEUTIC USE | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2011-11-09 | — | — | EP | claimed |