Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 10/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25814506 | 0.89 | TLR9 (0.44) | TLR9TLR8TLR7HTR1FKDM4E | |
| SCHEMBL25811844 | 0.83 | TLR9 (0.45) | TLR9TLR8TLR7HTR7HTR6 | |
| SCHEMBL25811207 | 0.79 | TLR8 (0.64) | TLR9TLR8TLR7HTR1FKDM4E | |
| SCHEMBL25814990 | 0.79 | TLR9 (0.46) | TLR9TLR8TLR7HTR1FHTR7 | |
| SCHEMBL25813335 | 0.79 | TLR8 (0.53) | TLR9TLR8TLR7HTR1FKDM4E | |
| SCHEMBL25811506 | 0.76 | KDM4E (0.67) | KDM4EPSMD14RECQLRXFP1TDP1 | |
| SCHEMBL25814053 | 0.74 | TLR9 (0.46) | TLR9TLR8TLR7KDM4EPSMD14 | |
| SCHEMBL25813827 | 0.74 | KDM4E (0.58) | TLR9TLR8TLR7KDM4EHCRTR1 | |
| SCHEMBL25811504 | 0.73 | HCRTR1 (0.74) | KDM4EHCRTR1SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL25812069 | 0.73 | CYP19A1 (0.44) | TLR9TLR8TLR7KDM4EHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | GALYAN BIO INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, HYPK, PARK7 | TLR9 4628/4885TLR8 4582/4885TLR7 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.