Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25812069 | 0.89 | CYP19A1 (0.44) | TLR9TLR8TLR7CYP19A1HCRTR1 | |
| SCHEMBL25814985 | 0.83 | TLR9 (0.52) | TLR9TLR8TLR7HCRTR1KDM4E | |
| SCHEMBL25811960 | 0.82 | KMT2A (0.47) | TLR9TLR8TLR7CYP19A1HCRTR1 | |
| SCHEMBL25811280 | 0.79 | ALDH1A1 (0.57) | TLR9TLR8TLR7CYP19A1KDM4E | |
| SCHEMBL27734682 | 0.76 | KDM4E (0.67) | CYP19A1HCRTR1KDM4EALDH1A1HPGD | |
| SCHEMBL25815032 | 0.74 | KMT2A (0.45) | TLR9TLR8TLR7CYP19A1HCRTR1 | |
| SCHEMBL25813827 | 0.74 | KDM4E (0.58) | TLR9TLR8TLR7HCRTR1KDM4E | |
| SCHEMBL25812014 | 0.73 | KMT2A (0.49) | TLR9TLR8TLR7CYP19A1KDM4E | |
| SCHEMBL2161298 | 0.73 | HCRTR1 (0.74) | CYP19A1HCRTR1KDM4EALDH1A1HPGD | |
| SCHEMBL25814506 | 0.73 | TLR9 (0.44) | TLR9TLR8TLR7HCRTR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | GALYAN BIO INC (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218573-A1 | INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | HTT, HYPK, PARK7 | TLR9 4628/4885TLR8 4582/4885TLR7 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.