Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 7/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581913 | 0.81 | POLQ (0.42) | P2RX7POLQNPSR1KDM4EALDH1A1 | |
| SCHEMBL3293530 | 0.73 | P2RX7 (0.57) | P2RX7TNKSTNKS2CYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL2581954 | 0.73 | P2RX7 (0.44) | P2RX7POLQTNKSTNKS2CYP2C9 | |
| SCHEMBL15534698 | 0.73 | P2RX7 (0.44) | P2RX7TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL20049209 | 0.72 | P2RX7 (0.48) | P2RX7POLQTNKSTNKS2CYP2C9 | |
| SCHEMBL400732 | 0.71 | TAS2R14 (0.47) | P2RX7LMNAKDM4EALDH1A1GAA | |
| SCHEMBL3617869 | 0.70 | RIPK1 (0.45) | P2RX7LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15534934 | 0.70 | P2RX7 (0.42) | P2RX7TNKSTNKS2CYP2C9CYP2C19 | |
| SCHEMBL1818639 | 0.69 | PTGDR2 (0.39) | POLQLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL545297 | 0.69 | NR1H2 (0.46) | POLQLMNAGAAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048907-B2 | Receptor antagonists and their methods of use | GLAXO GROUP LIMITED (GB) | 2011-11-01 | — | — | US | disclosed |