Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581524 | 0.81 | P2RX7 (0.44) | POLQP2RX7PTGS2KDM4EALDH1A1 | |
| SCHEMBL1362694 | 0.81 | MEN1 (0.41) | RIPK1KDM4EALDH1A1MEN1HTT | |
| SCHEMBL3617869 | 0.77 | RIPK1 (0.45) | P2RX7RIPK1KDM4EALDH1A1TDP1 | |
| SCHEMBL23607744 | 0.76 | CXCR2 (0.37) | RIPK1KDM4EALDH1A1MEN1HTT | |
| SCHEMBL305056 | 0.73 | PTGS2 (0.57) | POLQP2RX7PTGS2AKR1B1EPHX2 | |
| SCHEMBL29525642 | 0.73 | PTGS2 (0.57) | POLQP2RX7PTGS2AKR1B1EPHX2 | |
| SCHEMBL545297 | 0.73 | NR1H2 (0.46) | POLQEPHX2GAAMEN1HTT | |
| SCHEMBL1818639 | 0.73 | PTGDR2 (0.39) | POLQEPHX2ALDH1A1MEN1HTT | |
| SCHEMBL3759765 | 0.73 | L3MBTL1 (0.36) | RIPK1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL5415312 | 0.72 | GABRA1 (0.46) | POLQP2RX7AKR1B1EPHX2CD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048907-B2 | Receptor antagonists and their methods of use | GLAXO GROUP LIMITED (GB) | 2011-11-01 | — | — | US | disclosed |