SCHEMBL2581990

SCHEMBL2581990

CCOC(=O)C(C#N)=Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.67
MAPT P10636 9/20 0.67
KDM4E B2RXH2 3/20 0.67
TP53 P04637 1/20 0.64
PDCD1 Q15116 1/20 0.61
CD274 Q9NZQ7 1/20 0.61
PKM P14618 1/20 0.61
HTT P42858 1/20 0.61
KMT2A Q03164 6/20 0.60
MEN1 O00255 5/20 0.60
L3MBTL1 Q9Y468 2/20 0.60
TDP1 Q9NUW8 2/20 0.60
NPC1 O15118 1/20 0.60
MAPK1 P28482 1/20 0.60
CASP3 P42574 1/20 0.60
RAB9A P51151 1/20 0.60
SENP8 Q96LD8 1/20 0.60
SENP7 Q9BQF6 1/20 0.60
SENP6 Q9GZR1 1/20 0.60
DHODH Q02127 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2581988 1.00 ALDH1A1 (0.67) ALDH1A1MAPTKDM4ETP53PDCD1
SCHEMBL988238 0.91 MAPT (0.71) ALDH1A1MAPTKDM4ETP53PDCD1
SCHEMBL278655 0.91 MAPT (0.71) ALDH1A1MAPTKDM4ETP53PDCD1
SCHEMBL988236 0.91 MAPT (0.71) ALDH1A1MAPTKDM4ETP53PDCD1
SCHEMBL4317761 0.90 ALDH1A1 (0.81) ALDH1A1MAPTKDM4EPDCD1CD274
SCHEMBL2139678 0.90 ALDH1A1 (0.81) ALDH1A1MAPTKDM4EPDCD1CD274
SCHEMBL2139676 0.90 ALDH1A1 (0.81) ALDH1A1MAPTKDM4EPDCD1CD274
SCHEMBL15392279 0.88 MAPT (0.71) ALDH1A1MAPTKDM4ETP53PDCD1
SCHEMBL16131599 0.86 ALDH1A1 (0.64) ALDH1A1MAPTKDM4ETP53PDCD1
SCHEMBL15371833 0.86 ALDH1A1 (0.64) ALDH1A1MAPTKDM4ETP53PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3003031-A1 COATED PARTICLES AND COMPOSITIONS COMPRISING SAME Vyome Biosciences Pvt Ltd (IN) 2016-04-13 EP claimed
WO-2014195872-A1 COATED PARTICLES AND COMPOSITIONS COMPRISING SAME VYOME BIOSCIENCES PVT. LTD. (IN) 2014-12-11 WO claimed
US-20250195384-A1 COSMETIC SHISEIDO COMPANY, LTD. (JP) 2025-06-19 US disclosed
EP-4380553-A1 STABILISED COMPOSITIONS Rumin8 Pty Ltd (AU) 2024-06-12 EP disclosed
EP-4259693-A1 POLYMER TAKING THE FORM OF A PULVERULENT SOLID AND HAVING PROPERTIES FOR THICKENING POLAR MEDIA Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC (FR) 2023-10-18 EP disclosed
WO-2023010170-A1 STABILISED COMPOSITIONS Rumin8 Pty Ltd (AU) 2023-02-09 WO disclosed
US-20230018776-A1 RAW MATERIAL FOR COSMETIC AND OIL-IN-WATER EMULSION COSMETIC COMPRISING CORE-CORONA POLYMER PARTICLE SHISEIDO COMPANY, LTD. (JP) 2023-01-19 US disclosed
US-20220339091-A1 PHOTOCHEMICALLY STABLE, NON-LEACHING, BRIDGED POLYSILSESQUIOXANE BASED SUNSCREENS ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2022-10-27 US disclosed
EP-3897517-A1 OIL-IN-WATER COSMETIC AND METHOD FOR PRODUCING THE SAME L V M H RECHERCHE (FR) 2021-10-27 EP disclosed
WO-2020128557-A1 OIL-IN-WATER COSMETIC AND METHOD FOR PRODUCING THE SAME L V M H RECHERCHE (FR) 2020-06-25 WO disclosed
EP-3099301-A2 TREATMENTS FOR RESISTANT ACNE Vyome Biosciences Pvt Ltd (IN) 2016-12-07 EP disclosed
WO-2015114666-A9 TREATMENTS FOR RESISTANT ACNE VYOME BIOSCIENCES PVT. LTD. (IN) 2016-10-20 WO disclosed
EP-3003031-A1 COATED PARTICLES AND COMPOSITIONS COMPRISING SAME Vyome Biosciences Pvt Ltd (IN) 2016-04-13 EP disclosed
WO-2015114666-A2 TREATMENTS FOR RESISTANT ACNE VYOME BIOSCIENCES PVT. LTD. (IN) 2015-08-06 WO disclosed
WO-2014195872-A1 COATED PARTICLES AND COMPOSITIONS COMPRISING SAME VYOME BIOSCIENCES PVT. LTD. (IN) 2014-12-11 WO disclosed
WO-2013065767-A1 LONG CHAIN HYDROCARBON-MODIFIED SILICONE - AMINO-MODIFIED SILICONE COPOLYMER AND USES THEREOF DOW CORNING TORAY CO., LTD. (JP) 2013-05-10 WO disclosed
EP-2585033-A2 COSMETIC AND TOPICAL SKIN PREPARATION COMPRISING HIGHER ALCOHOL-MODIFIED SILICONE Dow Corning Toray Co., Ltd. (JP) 2013-05-01 EP disclosed
WO-2011136389-A2 COSMETIC AND TOPICAL SKIN PREPARATION COMPRISING HIGHER ALCOHOL-MODIFIED SILICONE DOW CORNING TORAY CO., LTD. (JP) 2011-11-03 WO disclosed
WO-1999036049-A1 PHOTOSTABLE UV ABSORBENT CONTAINING α-CYANO CINNAMYL MOIETY ISP INVESTMENTS INC. (US) 1999-07-22 WO disclosed
US-5830441-A SUNSCREEN AGENTS ISP INVESTMENTS INC. (US) 1998-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230018776-A1 RAW MATERIAL FOR COSMETIC AND OIL-IN-WATER EMULSION COSMETIC COMPRISING CORE-CORONA POLYMER PARTICLE CUTA, LIPA, CORO1A ALDH1A1 832/4885MAPT 2077/4885KDM4E 4224/4885
US-20220339091-A1 PHOTOCHEMICALLY STABLE, NON-LEACHING, BRIDGED POLYSILSESQUIOXANE BASED SUNSCREENS SQLE, STS, DSG1 ALDH1A1 1153/4885MAPT 1940/4885KDM4E 2352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.