Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25824322 | 0.84 | CRBN (0.41) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL25033939 | 0.83 | CRBN (0.60) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL30475454 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL25035194 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL25029389 | 0.81 | CRBN (0.53) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL25824646 | 0.81 | ADAMTS5 (0.40) | ALDH1A1KMT2ACRBNPDE3BPDE3A | |
| SCHEMBL25033922 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KMT2AHPGDMEN1LMNA | |
| SCHEMBL30479035 | 0.74 | CRBN (0.48) | ALDH1A1HPGDCRBNNPC1RAB9A | |
| SCHEMBL30984703 | 0.70 | CRBN (0.48) | LMNACRBNRAB9ADDB1TSHR | |
| SCHEMBL25575940 | 0.69 | CRBN (0.54) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912710-B2 | Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers | UPPTHERA, INC. (KR) | 2024-02-27 | — | — | US | disclosed |
| US-20230219966-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219966-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | ALDH1A1 4008/4885KMT2A 1840/4885HPGD 3219/4885 |
| US-11912710-B2 | Substituted pyrimido[4,5-b][1,4]diazepines as PLK1 degradation inducers | PLK1, BUB1B, BUB1 | ALDH1A1 2752/4885KMT2A 1115/4885HPGD 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.