SCHEMBL25825841

SCHEMBL25825841

CCOC(=O)Cc1noc2c3c(ccc12)CC1(C3)CN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.37
SCD5 Q86SK9 1/20 0.35
CYP11B2 P19099 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
RECQL P46063 1/20 0.33
LMNA P02545 2/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
GPR119 Q8TDV5 3/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
GRM5 P41594 1/20 0.32
GPR4 P46093 1/20 0.32
PARP1 P09874 1/20 0.32
JAK2 O60674 1/20 0.32
JAK1 P23458 1/20 0.32
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25825839 0.89 SMN1; SMN2 (0.40) SCD5CYP11B2SMN1; SMN2GPR119PARP1
SCHEMBL25825902 0.84 L3MBTL1 (0.39) L3MBTL1SMN1; SMN2RECQLLMNAALDH1A1
SCHEMBL25604356 0.83 ESR2 (0.39) L3MBTL1SMN1; SMN2RECQLLMNAALDH1A1
SCHEMBL25604199 0.82 ESR2 (0.43) L3MBTL1SMN1; SMN2RECQLLMNAJAK2
SCHEMBL25604265 0.78 L3MBTL1 (0.37) L3MBTL1SMN1; SMN2RECQLALDH1A1MEN1
SCHEMBL25826024 0.78 L3MBTL1 (0.37) L3MBTL1SMN1; SMN2RECQLALDH1A1MEN1
SCHEMBL25825838 0.74 ESR2 (0.35) L3MBTL1LMNAKMT2AGPR119CYP1A2
SCHEMBL31323712 0.74 CYP11B2 (0.47) L3MBTL1SCD5CYP11B2SMN1; SMN2LMNA
SCHEMBL25825901 0.72 SMN1; SMN2 (0.44) SCD5SMN1; SMN2GPR119
SCHEMBL25604635 0.72 SMN1; SMN2 (0.38) SMN1; SMN2RECQLALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023125944-A1 COMPOUND CONTAINING HETEROCYCLIC RING 正大天晴药业集团股份有限公司 2023-07-06 WO disclosed