Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132463 | 0.83 | BRD4 (0.44) | PKMHSD17B10TP53HPGDBRD4 | |
| SCHEMBL760693 | 0.81 | CCNB2 (0.37) | PKMTHRBTRIM24OPRK1PDE4D | |
| SCHEMBL21603583 | 0.81 | PKM (0.38) | PKMTHRBTRIM24OPRK1PDE4D | |
| SCHEMBL16132461 | 0.81 | CYP11B2 (0.40) | PKMBMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL29778811 | 0.81 | PKM (0.38) | PKMTHRBTRIM24OPRK1PDE4D | |
| SCHEMBL256751 | 0.77 | KMT2A (0.46) | THRBOPRK1PDE4DPOLBMEN1 | |
| SCHEMBL768709 | 0.72 | JAK2 (0.38) | TRIM24ALDH1A1GAA | |
| SCHEMBL24080922 | 0.72 | BRPF1 (0.40) | THRBOPRK1PDE4DLMNAMEN1 | |
| SCHEMBL2471070 | 0.71 | LMNA (0.35) | LMNAHSD17B10MEN1KMT2AMAPT | |
| SCHEMBL31528133 | 0.70 | HTT (0.37) | PKMPOLBTP53HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227472-A1 | FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD (CN) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227472-A1 | FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | KRAS, NRAS, WEE1 | PKM 2019/4885THRB 3148/4885TRIM24 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.