SCHEMBL25830459

SCHEMBL25830459

CC(=O)c1ccn(C(=O)N2CCN(Cc3ccc(N4CC5COCC5C4)cc3C(F)(F)F)CC2)n1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FAAH O00519 13/20 0.66
MGLL Q99685 5/20 0.56
PLA2G7 Q13093 1/20 0.44
ABHD6 Q9BV23 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20567171 0.92 FAAH (0.78) FAAHMGLL
SCHEMBL25830109 0.88 FAAH (0.84) FAAHMGLL
SCHEMBL20570835 0.88 FAAH (0.57) FAAHMGLLPLA2G7ABHD6
SCHEMBL21896198 0.86 FAAH (0.57) FAAHMGLLPLA2G7ABHD6
SCHEMBL25829842 0.84 MGLL (0.61) FAAHMGLL
SCHEMBL25830032 0.83 FAAH (0.68) FAAHMGLL
SCHEMBL25829996 0.81 MGLL (0.54) FAAHMGLLPLA2G7ABHD6
SCHEMBL25830003 0.80 MGLL (0.53) FAAHMGLLPLA2G7ABHD6
SCHEMBL20567162 0.80 FAAH (1.00) FAAHMGLL
SCHEMBL25830383 0.78 MGLL (0.88) FAAHMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2023-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219897-A1 PYRAZOLE MAGL INHIBITORS MGLL, PNLIP, LPL FAAH 33/4885MGLL 1/4885PLA2G7 48/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.