SCHEMBL25830902

SCHEMBL25830902

C=CC(=O)OCc1ccc(N(c2ccccc2)c2ccc(-c3ccc(CCC)cc3)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.50
LTB4R2 Q9NPC1 4/20 0.41
HCAR2 Q8TDS4 1/20 0.40
ALDH1A1 P00352 2/20 0.39
MCL1 Q07820 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
LMNA P02545 1/20 0.38
FFAR1 O14842 1/20 0.38
ENPP2 Q13822 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
MMP12 P39900 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26532016 0.95 THRB (0.55) THRBALDH1A1MCL1MAPTHPGD
SCHEMBL13777455 0.92 HCAR2 (0.45) THRBLTB4R2HCAR2ALDH1A1MAPT
SCHEMBL16625920 0.92 HCAR2 (0.45) THRBLTB4R2HCAR2ALDH1A1MAPT
SCHEMBL16625916 0.92 HCAR2 (0.45) THRBLTB4R2HCAR2ALDH1A1MAPT
SCHEMBL12534114 0.92 HCAR2 (0.45) THRBLTB4R2HCAR2ALDH1A1MAPT
SCHEMBL9915733 0.91 HCAR2 (0.44) THRBHCAR2ALDH1A1MAPTHPGD
SCHEMBL25830855 0.90 THRB (0.50) THRBMCL1ESR1ESR2MMP12
SCHEMBL13778858 0.90 HCAR2 (0.45) THRBHCAR2ALDH1A1MAPTHPGD
SCHEMBL172480 0.90 HCAR2 (0.45) THRBHCAR2ALDH1A1MAPTHPGD
SCHEMBL12727904 0.89 MMP12 (0.43) THRBHCAR2ALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12032318-B2 Electrophotographic image forming system with cleaning blade Konica Minolta, Inc. (JP) 2024-07-09 US disclosed
US-12032318-B2 Electrophotographic image forming system with cleaning blade Konica Minolta, Inc. (JP) 2024-07-09 US disclosed
US-20230185227-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2023-06-15 US disclosed
US-20230185227-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2023-06-15 US disclosed