Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21377019 | 0.81 | CDK9 (0.34) | KDM4EHTTCYP11B1CYP11B2ALOX15 | |
| SCHEMBL24477989 | 0.80 | CYP11B1 (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL24978482 | 0.80 | SSTR4 (0.31) | — | |
| SCHEMBL20861567 | 0.77 | CYP11B2 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL22020479 | 0.71 | PDE4A (0.36) | — | |
| SCHEMBL23107067 | 0.70 | MAP4K1 (0.40) | — | |
| SCHEMBL20861336 | 0.69 | CYP11B2 (0.35) | KDM4EHTTCYP11B1CYP11B2 | |
| SCHEMBL13684190 | 0.68 | — | — | |
| SCHEMBL20861635 | 0.65 | CYP11B1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL25031230 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702428-B2 | Chemical compounds as inhibitors of interleukin-1 activity | GENENTECH, INC. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702428-B2 | Chemical compounds as inhibitors of interleukin-1 activity | IL1B, IL1A, IL18 | KDM4E 4053/4885HTT 1446/4885CYP11B1 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.