SCHEMBL25845153

SCHEMBL25845153

OCc1cc(Cl)cc2c1OCO2

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.36
POLB P06746 1/20 0.35
BAD Q92934 1/20 0.34
MAOB P27338 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
CYP3A4 P08684 3/20 0.33
ALDH1A1 P00352 1/20 0.33
LTC4S Q16873 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
CYP2D6 P10635 1/20 0.32
APP P05067 1/20 0.32
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25844870 0.82 MAOB (0.34) POLBMAOBCYP3A4ALDH1A1LTC4S
SCHEMBL12467259 0.81 ALDH1A1 (0.39) POLBMAOBNPC1RAB9ACYP3A4
SCHEMBL26727604 0.77 POLB (0.38) ALOX5POLBBADKMT2ARAB9A
SCHEMBL7472315 0.77 CYP3A4 (0.35) ALOX5POLBBADCYP3A4ALDH1A1
SCHEMBL12553098 0.77 POLB (0.38) ALOX5POLBBADCYP3A4ALDH1A1
SCHEMBL14027056 0.77 POLB (0.35) ALOX5POLBBADMAOBMEN1
SCHEMBL25845077 0.77 POLB (0.35) ALOX5POLBBADCYP3A4ALDH1A1
SCHEMBL5271445 0.77 ALDH1A1 (0.35) POLBMAOBMEN1KMT2ACYP3A4
SCHEMBL11081166 0.75 AHR (0.47) MAOBMEN1KMT2ANPC1RAB9A
SCHEMBL15828714 0.73 CYP2C19 (0.36) POLBBADRAB9ACYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230339919-A1 BENZO OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICAL APPLICATION THEREOF AB Pharma Ltd. (CN) 2023-10-26 US disclosed
US-20230339919-A1 BENZO OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICAL APPLICATION THEREOF AB Pharma Ltd. (CN) 2023-10-26 US disclosed
EP-4212528-A1 BENZO OXYGEN-CONTAINING HETEROCYCLIC COMPOUND AND MEDICAL APPLICATION THEREOF AB Pharma Ltd. (CN) 2023-07-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230339919-A1 BENZO OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICAL APPLICATION THEREOF GPR55, GPR65, GPR4 ALOX5 687/4885POLB 1892/4885BAD 1714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.