SCHEMBL25845385

SCHEMBL25845385

CCCNC(=O)CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OC(C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TLR2 O60603 4/20 0.54
▸ MDM4 O15151 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ MDM2 Q00987 1/20 0.45
▸ KMT2A Q03164 1/20 0.44
▸ BCHE P06276 1/20 0.44
▸ ACHE P22303 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12231705 0.92 TLR2 (0.50) TLR2MDM4TP53MDM2KMT2A
SCHEMBL30973621 0.92 TLR2 (0.50) TLR2MDM4TP53MDM2KMT2A
SCHEMBL463455 0.92 TLR2 (0.50) TLR2MDM4TP53MDM2KMT2A
SCHEMBL23447188 0.92 TLR2 (0.56) TLR2MDM4TP53MDM2KMT2A
SCHEMBL18709106 0.91 TLR2 (0.49) TLR2MDM4TP53MDM2KMT2A
SCHEMBL27094843 0.90 TLR2 (0.51) TLR2MDM4TP53MDM2KMT2A
SCHEMBL23447164 0.89 TLR2 (0.52) TLR2MDM4TP53MDM2BCHE
SCHEMBL23927996 0.89 TLR2 (0.49) TLR2MDM4TP53MDM2KMT2A
SCHEMBL23927994 0.89 TLR2 (0.49) TLR2MDM4TP53MDM2KMT2A
SCHEMBL26044456 0.89 TLR2 (0.60) TLR2MDM2KMT2ABCHEACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230265429-A1 SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF Arrowhead Pharmaceuticals, Inc. 2023-08-24 — — US disclosed
US-20230226193-A1 LIPID CONJUGATES FOR THE DELIVERY OF THERAPEUTIC AGENTS Arrowhead Pharmaceuticals, Inc. 2023-07-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230226193-A1 LIPID CONJUGATES FOR THE DELIVERY OF THERAPEUTIC AGENTS CPT1B, MUSK, MYLK2 TLR2 3714/4885MDM4 4317/4885TP53 4012/4885
US-20230265429-A1 SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF MUSK, MYLK2, TNNC1 TLR2 3599/4885MDM4 4563/4885TP53 4218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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