SCHEMBL25849817

SCHEMBL25849817

CN(c1ccccc1)c1ccc(C2=C3C(=O)N(c4ccccc4)C(c4ccc(N(C)c5ccccc5)cc4)=C3C(=O)N2c2ccccc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.40
ALDH1A1 P00352 4/20 0.40
MAPT P10636 2/20 0.40
GFER P55789 1/20 0.40
GSK3B P49841 2/20 0.39
APP P05067 1/20 0.37
SNCA P37840 1/20 0.37
NR3C2 P08235 1/20 0.37
NOX4 Q9NPH5 2/20 0.36
NOX1 Q9Y5S8 1/20 0.36
CYBB P04839 1/20 0.36
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
RAB9A P51151 1/20 0.36
RECQL P46063 1/20 0.35
RAD51 Q06609 1/20 0.35
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10050139 0.84 APP (0.42) GAAALDH1A1MAPTGFERAPP
SCHEMBL10050140 0.82 KMT2A (0.40) GAAALDH1A1APPKDM4EMEN1
SCHEMBL5068959 0.81 MGLL (0.46) GAAALDH1A1MEN1KMT2ARAD51
SCHEMBL25849820 0.77 NR1H2 (0.42) GAAALDH1A1MAPTGSK3BNR3C2
SCHEMBL27575223 0.76 NR1H2 (0.45) GAAALDH1A1MEN1KMT2ARAD51
SCHEMBL9836388 0.73 F2 (0.48) GAAALDH1A1MAPTLMNAKDM4E
SCHEMBL5110493 0.73 ALDH1A1 (0.40) GAAALDH1A1MAPTLMNAMEN1
SCHEMBL23954215 0.72 HSP90AA1 (0.51) GAAALDH1A1MAPTLMNAMEN1
SCHEMBL7062361 0.71 MGLL (0.61) ALDH1A1MGLLFAAHHSP90AA1HPGD
SCHEMBL13152124 0.71 CHKA (0.55) ALDH1A1MAPTGFERGSK3BNR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230232713-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND FUJIFILM CORPORATION (JP) 2023-07-20 US disclosed