Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581672 | 0.79 | DRD4 (0.53) | LMNA | |
| SCHEMBL2585658 | 0.79 | CCR2 (0.46) | SMYD3 | |
| SCHEMBL2576007 | 0.74 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL2586740 | 0.73 | MAPT (0.53) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL4268544 | 0.73 | CD4 (0.45) | KMT2AALDH1A1PKMGAA | |
| SCHEMBL5539258 | 0.71 | KMT2A (0.43) | MEN1KMT2AALDH1A1LMNAPKM | |
| SCHEMBL2576115 | 0.70 | LMNA (0.52) | MEN1KMT2AALDH1A1LMNAPKM | |
| SCHEMBL2584665 | 0.70 | NPC1 (0.48) | MEN1KMT2APKMTSHRSMN1; SMN2 | |
| SCHEMBL2581162 | 0.69 | RAB9A (0.58) | MEN1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL2586164 | 0.69 | MAPT (0.43) | MEN1KMT2AALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |