SCHEMBL25857032

SCHEMBL25857032

N/C(=N\C(=O)Nc1ccccn1)Nc1ccccn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 8/20 0.58
NPC1 O15118 7/20 0.58
PKM P14618 3/20 0.58
GAA P10253 1/20 0.54
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
ADORA3 P0DMS8 1/20 0.50
PIM1 P11309 1/20 0.50
ADORA2A P29274 1/20 0.50
ADORA2B P29275 1/20 0.50
ADORA1 P30542 1/20 0.50
FLT3 P36888 1/20 0.50
PIM3 Q86V86 1/20 0.50
AURKB Q96GD4 1/20 0.50
GRM5 P41594 2/20 0.49
ADRA2A P08913 1/20 0.48
ADRA2B P18089 1/20 0.48
ADRA2C P18825 1/20 0.48
KDM4E B2RXH2 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25857038 0.91 NPC1 (0.60) RAB9ANPC1PKMGAAMEN1
SCHEMBL1486005 0.81 NPC1 (0.63) RAB9ANPC1PKMGAAMEN1
SCHEMBL9565723 0.79 NPC1 (0.55) RAB9ANPC1PKMGAAMEN1
SCHEMBL438214 0.78 RAB9A (0.70) RAB9ANPC1PKMGAAMEN1
SCHEMBL4564658 0.76 RAB9A (0.61) RAB9ANPC1PKMGAAMEN1
SCHEMBL4395297 0.75 RAB9A (0.78) RAB9ANPC1PKMGAAMEN1
SCHEMBL9750118 0.74 NPC1 (0.81) RAB9ANPC1PKMGAAMEN1
SCHEMBL30565139 0.74 RAB9A (1.00) RAB9ANPC1PKMGAAMEN1
SCHEMBL2782158 0.73 NPC1 (0.49) RAB9ANPC1PKMGAAMEN1
SCHEMBL17620897 0.73 NPC1 (0.49) RAB9ANPC1PKMGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11801228-B2 Modified guanidine-containing polymers for biologic delivery THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-10-31 US disclosed
US-20230225982-A1 MODIFIED GUANIDINE-CONTAINING POLYMERS FOR BIOLOGIC DELIVERY THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230225982-A1 MODIFIED GUANIDINE-CONTAINING POLYMERS FOR BIOLOGIC DELIVERY GMPS, RNMT, GUCY1A1 RAB9A 1420/4885NPC1 1081/4885PKM 2211/4885
US-11801228-B2 Modified guanidine-containing polymers for biologic delivery GMPS, RNMT, GUCY1A1 RAB9A 1420/4885NPC1 1081/4885PKM 2211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.