SCHEMBL25857050

SCHEMBL25857050

C=CC1OC(C=C)C2C(=O)N(CCNC(=S)/N=C(\N)NCc3ccccc3)C(=O)C12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
GRIN2D O15399 2/20 0.34
GRIN3B O60391 2/20 0.34
GRIN1 Q05586 2/20 0.34
GRIN2A Q12879 2/20 0.34
GRIN2B Q13224 2/20 0.34
GRIN2C Q14957 2/20 0.34
GRIN3A Q8TCU5 2/20 0.34
SIGMAR1 Q99720 2/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.33
MEN1 O00255 2/20 0.32
GAA P10253 2/20 0.32
KMT2A Q03164 2/20 0.32
HPGD P15428 1/20 0.32
ALOX12 P18054 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ELANE P08246 1/20 0.32
QPCT Q16769 1/20 0.32
MC4R P32245 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25857056 0.89 ALDH1A1 (0.46) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL25857073 0.87 ALDH1A1 (0.42) ALDH1A1LMNAMEN1GAAKMT2A
SCHEMBL25857068 0.87 ALDH1A1 (0.46) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL25857077 0.83 ALDH1A1 (0.41) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL24746999 0.83 ALDH1A1 (0.36) ALDH1A1
SCHEMBL25857071 0.81 MEN1 (0.35) ALDH1A1MEN1KMT2A
SCHEMBL25857062 0.78 ALDH1A1 (0.45) ALDH1A1MEN1KMT2AHPGDSMN1; SMN2
SCHEMBL25857060 0.77 ALDH1A1 (0.45) ALDH1A1MEN1KMT2AHPGDSMN1; SMN2
SCHEMBL24746658 0.75 ALDH1A1 (0.52) ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL25857181 0.74 ALDH1A1 (0.38) ALDH1A1LMNAMEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11801228-B2 Modified guanidine-containing polymers for biologic delivery THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-10-31 US disclosed
US-20230225982-A1 MODIFIED GUANIDINE-CONTAINING POLYMERS FOR BIOLOGIC DELIVERY THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230225982-A1 MODIFIED GUANIDINE-CONTAINING POLYMERS FOR BIOLOGIC DELIVERY GMPS, RNMT, GUCY1A1 ALDH1A1 1829/4885GRIN2D 4742/4885GRIN3B 3977/4885
US-11801228-B2 Modified guanidine-containing polymers for biologic delivery GMPS, RNMT, GUCY1A1 ALDH1A1 1829/4885GRIN2D 4742/4885GRIN3B 3977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.