Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CTSE | P14091 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491074 | 0.89 | KDM4E (0.47) | KDM4EPKMALDH1A1MEN1MAPT | |
| SCHEMBL1491087 | 0.84 | PKM (0.49) | KDM4EPKMALDH1A1MEN1MAPT | |
| SCHEMBL15651998 | 0.76 | OPRM1 (0.43) | PDE8BCTSDCTSEBACE1PIK3CD | |
| SCHEMBL1958192 | 0.74 | FEN1 (0.40) | PDE8BCTSDCTSEBACE1PIK3CD | |
| SCHEMBL25857669 | 0.72 | PKM (0.44) | PDE8BPKMRETCTSDCTSE | |
| SCHEMBL21960869 | 0.72 | L3MBTL1 (0.42) | PDE8BRETCTSDCTSEBACE1 | |
| SCHEMBL21964543 | 0.72 | EED (0.43) | PDE8BPKMRETCTSDCTSE | |
| SCHEMBL1957095 | 0.71 | LMNA (0.46) | KDM4EPKMALDH1A1PIK3CA | |
| Hydrochloric Acid SCHEMBL25215203 | 0.71 | PDE8B (0.36) | PDE8BRETCTSDCTSEBACE1 | |
| SCHEMBL9941718 | 0.70 | DDB1 (0.40) | PDE8BPKMRETPIK3CDCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107723-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |