Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585817 | 1.00 | RIPK1 (0.40) | RIPK1CALCRLALDH1A1TDP1PDE5A | |
| SCHEMBL2585730 | 0.89 | FFAR2 (0.34) | RIPK1FFAR2 | |
| SCHEMBL2585734 | 0.89 | FFAR2 (0.34) | RIPK1FFAR2 | |
| SCHEMBL2588033 | 0.88 | FFAR2 (0.38) | RIPK1ALDH1A1TDP1PDE5AFFAR2 | |
| SCHEMBL2588032 | 0.88 | FFAR2 (0.38) | RIPK1ALDH1A1TDP1PDE5AFFAR2 | |
| SCHEMBL2584598 | 0.86 | MEN1 (0.35) | FFAR2KDM4EHCRTR2 | |
| SCHEMBL2584599 | 0.86 | MEN1 (0.35) | FFAR2KDM4EHCRTR2 | |
| SCHEMBL2583870 | 0.84 | NTRK1 (0.33) | RIPK1ALDH1A1HCRTR2 | |
| SCHEMBL2583867 | 0.84 | NTRK1 (0.33) | RIPK1ALDH1A1HCRTR2 | |
| SCHEMBL4514302 | 0.83 | RIPK1 (0.37) | RIPK1CALCRLALDH1A1PDE5ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048878-B2 | Two cyclic cinnamide compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-11-01 | — | — | US | disclosed |