Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 12/20 | 0.43 |
| ▸ | CDK1 | P06493 | 11/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MGMT | P16455 | 7/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,6-Diaminopurine SCHEMBL7801065 | 0.80 | PDPK1 (0.55) | PDPK1GDACDK2CDK1CCNB1 | |
| SCHEMBL8720826 | 0.79 | PDPK1 (0.43) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL10774603 | 0.78 | PDPK1 (0.59) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL2934952 | 0.78 | PDPK1 (0.59) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL6241914 | 0.78 | PDPK1 (0.59) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL28206545 | 0.77 | PDPK1 (0.96) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL10520728 | 0.76 | MAPK1 (0.57) | PDPK1GDADPP4ADORA2AADORA1 | |
| 2,6-Diaminopurine SCHEMBL28083713 | 0.75 | PDPK1 (0.79) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL24053 | 0.75 | PDPK1 (1.00) | PDPK1GDACDK2CDK1CCNB1 | |
| 2,6-Diaminopurine SCHEMBL443468 | 0.75 | PDPK1 (0.55) | PDPK1GDACDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563367-A1 | METHODS OF TREATING RETROVIRAL INFECTIONS AND RELATED DOSAGE REGIMES | Chimerix, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139709-A2 | METHODS OF TREATING RETROVIRAL INFECTIONS AND RELATED DOSAGE REGIMES | CHIMERIX, INC. (US) | 2011-11-10 | — | — | WO | disclosed |