SCHEMBL25867610

SCHEMBL25867610

O=C1OC2(COC2)c2cc(I)ccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 2/20 0.39
SIGMAR1 Q99720 1/20 0.35
AVPR1A P37288 4/20 0.32
CFTR P13569 1/20 0.32
GOPC Q9HD26 1/20 0.32
TGM2 P21980 1/20 0.32
CES1 P23141 1/20 0.32
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
THRB P10828 1/20 0.31
CDK2 P24941 1/20 0.31
CHAT P28329 1/20 0.31
BLVRB P30043 1/20 0.31
RECQL P46063 1/20 0.31
BLM P54132 1/20 0.31
KMT2A Q03164 1/20 0.31
ACE2 Q9BYF1 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25866294 0.80 OPRM1 (0.43) TDP2SIGMAR1AVPR1AMEN1KMT2A
SCHEMBL31178327 0.77 SIGMAR1 (0.54) SIGMAR1AVPR1ACFTRGOPCMEN1
SCHEMBL29922337 0.74 OPRM1 (0.41) TDP2SIGMAR1AVPR1AMEN1KMT2A
SCHEMBL14273273 0.74 TDP2 (0.39) TDP2CFTRGOPCTGM2CES1
SCHEMBL25313161 0.70 AVPR1A (0.47) AVPR1AMEN1RECQLBLMKMT2A
SCHEMBL31394738 0.70 AVPR1A (0.47) TDP2SIGMAR1AVPR1ATGM2CES1
SCHEMBL26023399 0.70 AVPR1A (0.47) SIGMAR1AVPR1ALRRK2CA7
SCHEMBL29921913 0.66 POLB (0.41) TDP2MEN1BLMKMT2ATDP1
SCHEMBL29922364 0.65 NPY5R (0.43) SIGMAR1AVPR1AKMT2A
SCHEMBL29922416 0.65 POLB (0.40) TDP2SIGMAR1AVPR1AMEN1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023134656-A1 PEPTIDYL NITRILE COMPOUND AND USE THEREOF 上海壹典医药科技开发有限公司 2023-07-20 WO disclosed