Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 7/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | ENO1 | P06733 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24724733 | 0.91 | ALDH1A1 (0.46) | VCPHDAC6TPH1CNR2HDAC1 | |
| SCHEMBL23346071 | 0.90 | HDAC6 (0.40) | VCPHDAC6TPH1CNR2HDAC1 | |
| SCHEMBL21479645 | 0.90 | HDAC6 (0.40) | VCPHDAC6TPH1CNR2HDAC1 | |
| SCHEMBL24933040 | 0.85 | LMNA (0.42) | VCPCNR2HTTHPGDSMN1; SMN2 | |
| SCHEMBL23386772 | 0.81 | ENO1 (0.55) | HDAC6HDAC1ENO1SMN1; SMN2 | |
| SCHEMBL13607364 | 0.81 | ENO1 (0.55) | HDAC6HDAC1ENO1SMN1; SMN2 | |
| SCHEMBL24724735 | 0.80 | ENO1 (0.43) | HDAC6ENO1ACACB | |
| SCHEMBL24724746 | 0.78 | CNR2 (0.37) | VCPTPH1CNR2ENO1 | |
| SCHEMBL24724734 | 0.77 | TPH1 (0.39) | TPH1CNR2EPHX1 | |
| SCHEMBL25897581 | 0.72 | HDAC6 (0.41) | VCPHDAC6TPH1HDAC1ENO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | UNIV YALE (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233689-A1 | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins | ASGR1, LDLR, FCGR2A | VCP 3148/4885HDAC6 4094/4885TPH1 3887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.