Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 4/20 | 0.66 |
| ▸ | CD44 | P16070 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL985673 | 0.95 | PNMT (0.63) | PNMTCD44MAOBHTR2CALOX15 | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28542017 | 0.91 | PNMT (0.73) | PNMTCD44MAOBHTR2CALOX15 | |
| Indoline SCHEMBL2426723 | 0.85 | MAPT (0.47) | PNMTCD44MAOBHTR2CALOX15 | |
| SCHEMBL18172 | 0.85 | MAPT (0.50) | PNMTCD44MAOBHTR2CALOX15 | |
| SCHEMBL27392334 | 0.85 | MAPT (0.50) | PNMTCD44MAOBHTR2CALOX15 | |
| SCHEMBL29370549 | 0.85 | MAPT (0.50) | PNMTCD44MAOBHTR2CALOX15 | |
| Piperazine SCHEMBL28330011 | 0.83 | HTR2C (0.48) | PNMTCD44MAOBHTR2CALOX15 | |
| SCHEMBL8215775 | 0.83 | MAPT (0.48) | PNMTCD44MAOBHTR2CALOX15 | |
| Hydrochloric Acid SCHEMBL5370795 | 0.83 | MAPT (0.48) | HTR2CALOX15HSD17B10TSHRADRA2A | |
| Phosphine SCHEMBL241499 | 0.83 | MAPT (0.48) | PNMTCD44MAOBHTR2CALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131043-A1 | PYRAZOLE COMPOUNDS AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2013-05-23 | — | — | US | claimed |
| EP-2566867-A1 | PYRAZOLE COMPOUNDS AS JAK INHIBITORS | Cellzome Limited (GB) | 2013-03-13 | — | — | EP | claimed |
| WO-2011134831-A1 | PYRAZOLE COMPOUNDS AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-11-03 | — | — | WO | claimed |
| US-20130131043-A1 | PYRAZOLE COMPOUNDS AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2013-05-23 | — | — | US | disclosed |
| CN-100427513-C | Catalyst for polymerization or copolymerization of alpha-olefin, catalyst component therefor, and method for polymerization of alpha-olefin using the catalyst | UBE INDUSTRIES (JP) | 2008-10-22 | — | — | CN | disclosed |
| CN-1675255-A | Catalyst for polymerization or copolymerization of alpha-olefin, catalyst component therefor, and method for polymerization of alpha-olefin using the catalyst | UBE INDUSTRIES (JP) | 2005-09-28 | — | — | CN | disclosed |
| CN-1162452-C | Process for polymerization of alpha-olefins, polyalphaolefins prepared thereby, and aminosilane compounds useful as components of catalysts for such process | 三井化学株式会社 | 2004-08-18 | — | — | CN | disclosed |
| CN-1184120-A | Process for polymerization of alpha-olefins, polyalphaolefins prepared thereby, and aminosilane compounds useful as components of catalysts for such process | GRAND POLYMER CO LTD (JP) | 1998-06-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131043-A1 | PYRAZOLE COMPOUNDS AS JAK INHIBITORS | JAK1, JAK3, JAK2 | PNMT 3463/4885CD44 4515/4885MAOB 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.