SCHEMBL25870317

SCHEMBL25870317

Cc1cc([C@@H]2[C@@H](C=O)C2(Cl)Cl)cc(C(F)(F)F)c1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.34
NOTUM Q6P988 1/20 0.31
RAPGEF4 Q8WZA2 2/20 0.31
PGK1 P00558 1/20 0.30
PGK2 P07205 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23961605 0.89 CES2 (0.34) FFAR4
SCHEMBL30138711 0.89 CES2 (0.34) FFAR4
SCHEMBL25304836 0.89 CES2 (0.34) FFAR4
SCHEMBL21018992 0.78 SLC9A1 (0.35) FFAR4
SCHEMBL23466013 0.77 FFAR4 (0.40) FFAR4PGK1PGK2
SCHEMBL25870304 0.77 FFAR4 (0.40) FFAR4PGK1PGK2
SCHEMBL21022280 0.75 FFAR4 (0.36) FFAR4
SCHEMBL25870323 0.73 MEN1 (0.36) FFAR4NOTUM
SCHEMBL25870348 0.72 GPR35 (0.39) FFAR4
SCHEMBL20076857 0.71 IDH1 (0.33) FFAR4RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230220427-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS CORTEVA AGRISCIENCE LLC (US) 2023-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230220427-A1 PROCESSES RELATED TO FORMATION OF ARYLCYCLOPROPYL CARBOXYLIC ACIDS DDT, PCCA, DDC FFAR4 1179/4885NOTUM 177/4885RAPGEF4 1117/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.